Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation
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چکیده
منابع مشابه
The protective effect of allopurinol on cholestatic liver injury induced by bile duct ligation.
To determine whether oxygen free radicals are responsible for the pathogenesis of the cholestasis induced by ligation of common bile duct (CBD) variables which reflect the hepatic function in the serum, the amount of superoxide radical production, and xanthine oxidase(XO) activity were studied. The activity of serum alanine aminotransferase, bilirubin level in the serum and the amount of supero...
متن کاملTetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis.
Tetrathiomolybdate (TM), a potent copper-chelating drug, was initially developed for the treatment of Wilson's disease. Our working hypothesis is that the fibrotic pathway is copper-dependent. Because biliary excretion is the major pathway for copper elimination, a bile duct ligation (BDL) mouse model was used to test the potential protective effects of TM. TM was given in a daily dose of 0.9 m...
متن کاملInduction of Rat Liver Alkaline Phosphatase by Bile Duct Ligation
Bile duct ligation causes a five- to sevenfold increase in the activity of rat liver alkaline phosphatase within 12 hours after ligation and a similar rise in the activity of alkaline phosphatase in serum. The increased serum activity is due entirely to the appearance of a new isoenzyme that has the properties of rat liver alkaline phosphatase. The increase in both serum and liver alkaline phos...
متن کاملRenal expression of aquaporins in liver cirrhosis induced by chronic common bile duct ligation in rats.
Semiquantitative immunoblotting was used to investigate the expression levels of the four major renal aquaporins, the Na-K-2Cl cotransporter of the thick ascending limb, the type 3 Na-H exchanger, and the Na-K-ATPase in kidneys from rats with cirrhosis secondary to common bile duct ligation (CBDL). These rats had significant water retention and hyponatremia. In contrast to models of cirrhosis i...
متن کاملThe Protective Effects of Magnesium on Liver Tissue Alteration Induced by Bile Duct Ligation in Rat
Magnesium is the fourth most abundant cation in the body and the second most abundant cation in intracellular fluid. Magnesium plays an important role in numerous biological functions. In the present study we investigated the effect of magnesium sulfate (MgSO4) on histological abnormalities induced by bile duct ligation in male Wistar rats. The effects of 28-day oral administration of MgSO4 (at...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2001
ISSN: 2092-6413
DOI: 10.1038/emm.2001.5